Acetaminophen/Caffeine/Isometheptene
This multi-ingredient medication combines an analgesic (acetaminophen), a stimulant (caffeine), and a vasoconstrictor (isometheptene) to treat tension headaches and migraines. The three components work synergistically to relieve pain through different pathways. It is typically prescribed for adults experiencing moderate to severe headache pain.
A combination headache medication that uses three mechanisms—pain relief, vasoconstriction, and enhanced absorption—to address tension headaches and migraines.
Key facts at a glance
- RxNorm
- 689572
- Generic
- Acetaminophen / Caffeine / Isometheptene
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for tension-type headaches and migraine headaches in adults. May also be prescribed for other headache disorders where vasoconstriction and analgesia are beneficial.
Acetaminophen provides analgesic and fever-reducing effects by affecting the pain threshold in the central nervous system. Caffeine enhances the absorption and effectiveness of acetaminophen while providing mild vasoconstriction. Isometheptene acts as a vasoconstrictor, helping to reduce the dilation of blood vessels in the brain that contributes to headache pain.
Should not be used by patients with cardiovascular disease, hypertension, liver problems, or those taking MAO inhibitors. May interact with other medications including blood thinners and other headache treatments. Prolonged or frequent use should be avoided to prevent medication-overuse headaches. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy