Acetaminophen/Caffeine/Magnesium Salicylate/Phenyltoloxamine
This combination medication provides multi-modal pain relief by combining different mechanisms: acetaminophen for pain and fever reduction, caffeine to enhance analgesic effects and constrict blood vessels, magnesium salicylate for anti-inflammatory action, and phenyltoloxamine for additional analgesic and antihistamine effects. It is typically used for tension headaches, muscle aches, menstrual cramps, and other mild to moderate pain conditions.
A multi-ingredient analgesic combining acetaminophen, caffeine, a salicylate, and an antihistamine for enhanced pain relief.
Key facts at a glance
- RxNorm
- 1007522
- Generic
- Acetaminophen / Caffeine / Magnesium Salicylate / Phenyltoloxamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tension headaches, muscle aches, back pain, menstrual cramps, minor arthritis pain, and other mild to moderate pain conditions. May also be used for pain associated with sinus congestion.
The combination targets pain through multiple pathways: acetaminophen provides central nervous system pain relief, caffeine enhances the effectiveness of other analgesics and can help constrict dilated blood vessels associated with headaches, magnesium salicylate provides anti-inflammatory effects as an NSAID, and phenyltoloxamine adds antihistamine and mild sedative properties.
Avoid alcohol while taking this medication due to increased liver risk from acetaminophen. Use caution if you have stomach ulcers, bleeding disorders, or kidney problems due to the salicylate component. Do not take with other acetaminophen or NSAID products. Consult a healthcare provider if pain persists beyond 10 days or if you have liver disease. Not recommended during pregnancy without medical advice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy