Acetaminophen/Caffeine/Phenylephrine
This combination medication is used to temporarily relieve multiple cold and flu symptoms including headache, fever, body aches, nasal congestion, and sinus pressure. It combines a pain reliever/fever reducer, a mild stimulant, and a decongestant to address both discomfort and congestion. This medication is typically available over-the-counter for short-term use in adults and children.
A multi-symptom cold and flu relief medication combining pain/fever relief, caffeine, and a nasal decongestant.
Key facts at a glance
- RxNorm
- 817911
- Generic
- Acetaminophen / Caffeine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves common cold, flu, and sinus symptoms such as headache, fever, minor body aches, nasal congestion, and sinus pressure. Often marketed for daytime use due to its non-drowsy formula.
Acetaminophen reduces pain and fever by affecting the body's temperature regulation and pain pathways. Caffeine acts as a mild stimulant that may enhance acetaminophen's effectiveness and reduce drowsiness. Phenylephrine is a nasal decongestant that works by constricting blood vessels in the nasal passages, reducing swelling and congestion.
Do not exceed recommended doses as excessive acetaminophen can cause liver damage. Avoid use with other acetaminophen products. Consult a healthcare provider if you have high blood pressure, heart disease, thyroid disorders, or are pregnant/nursing. Not recommended for children under certain ages without medical advice.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy