Acetaminophen/Caffeine/Phenylpropanolamine/Salicylamide
This combination medication contains four active ingredients: acetaminophen for pain and fever relief, caffeine to enhance analgesic effects and reduce drowsiness, phenylpropanolamine as a decongestant, and salicylamide for additional pain relief. It is typically used to treat symptoms of cold, flu, sinus congestion, and mild to moderate pain such as headaches or muscle aches.
A multi-symptom cold and pain relief medication combining analgesics with a decongestant.
Key facts at a glance
- RxNorm
- 689574
- Generic
- Acetaminophen / Caffeine / Phenylpropanolamine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with common cold, flu, sinus congestion, allergies, and mild to moderate pain including headaches, toothaches, muscle aches, and menstrual cramps. May also help reduce fever.
Acetaminophen and salicylamide work by blocking pain signals in the nervous system. Caffeine acts as a mild stimulant and may enhance the effectiveness of pain relievers. Phenylpropanolamine is a sympathomimetic decongestant that narrows blood vessels in the nasal passages to reduce congestion.
Should not be used with other products containing acetaminophen to avoid overdose. Not recommended for individuals with certain heart conditions, high blood pressure, thyroid disorders, or those taking MAO inhibitors. Avoid alcohol while taking this medication. Consult a healthcare provider before use if pregnant, breastfeeding, or giving to children.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy