Acetaminophen/Caffeine/Phenyltoloxamine
Acetaminophen/Caffeine/Phenyltoloxamine is a combination analgesic medication used primarily to treat tension headaches, mild to moderate pain, and sinus discomfort. Acetaminophen provides pain relief and fever reduction, caffeine enhances the analgesic effect and may help constrict blood vessels to relieve headache, while phenyltoloxamine (an antihistamine) provides relief from allergic symptoms and can have a mild sedative effect.
A combination analgesic for tension headaches and mild pain with antihistamine properties.
Key facts at a glance
- RxNorm
- 615170
- Generic
- Acetaminophen / Caffeine / Phenyltoloxamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Tension-type headaches, mild to moderate pain (headache, toothache, muscle ache, menstrual cramps), sinus pressure, and pain associated with allergies or colds.
Acetaminophen inhibits COX enzymes in the brain to reduce pain and fever. Caffeine acts as a mild stimulant that may enhance analgesic effects and cause vasoconstriction. Phenyltoloxamine is an antihistamine that blocks histamine receptors and may help reduce sinus congestion and provide mild sedation.
Should not be combined with alcohol. Use caution if taking other products containing acetaminophen to avoid exceeding maximum daily dose. May cause drowsiness; avoid driving until you know how it affects you. Consult a healthcare provider if you have liver disease, glaucoma, or urinary problems before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy