Acetaminophen/Caffeine/Phenyltoloxamine/Salicylamide
This combination medication contains four active ingredients that work together to provide relief from pain and discomfort. Acetaminophen and salicylamide are analgesics that help relieve pain and reduce fever, while caffeine may enhance the effectiveness of these pain relievers. Phenyltoloxamine is an antihistamine that may help with tension-related symptoms and provide mild sedative effects. This combination is typically used for tension headaches, muscle aches, menstrual cramps, and other mild to moderate pain conditions.
A multi-ingredient analgesic combining two pain relievers with caffeine and an antihistamine for enhanced relief of tension headaches and mild to moderate pain.
Key facts at a glance
- RxNorm
- 606797
- Generic
- Acetaminophen / Caffeine / Phenyltoloxamine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for tension headaches, mild to moderate pain, muscle aches, menstrual cramps, and occasionally for fever reduction. The combination targets both pain and associated tension or stress symptoms.
Acetaminophen and salicylamide work as analgesics to block pain signals in the nervous system. Caffeine acts as a mild stimulant and may enhance the effectiveness of the analgesic components. Phenyltoloxamine provides antihistamine and mild sedative effects that may help with tension-related discomfort.
Should not be used by individuals with aspirin allergy due to the salicylamide component. Caution advised for those with liver disease (due to acetaminophen), stomach ulcers, or bleeding disorders. Avoid alcohol during use. Not recommended during pregnancy or breastfeeding without medical consultation. Do not exceed recommended doses to prevent liver damage from acetaminophen.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy