Acetaminophen/Caffeine/Pyrilamine
This combination medication contains three active ingredients that work together to provide relief from menstrual symptoms. Acetaminophen serves as a pain reliever and fever reducer, caffeine helps enhance pain relief and reduce bloating, while pyrilamine (an antihistamine) addresses fluid retention and irritability. This medication is primarily marketed for women experiencing menstrual cramps, premenstrual syndrome (PMS), and related discomfort.
A multi-ingredient medication for menstrual pain relief combining a pain reliever, stimulant, and antihistamine.
Key facts at a glance
- RxNorm
- 214137
- Generic
- Acetaminophen / Caffeine / Pyrilamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of menstrual cramps, premenstrual syndrome (PMS) symptoms, bloating, fatigue, headaches, and muscle aches associated with the menstrual cycle.
Acetaminophen provides analgesic (pain-relieving) effects, caffeine acts as a mild stimulant and may enhance pain relief while reducing bloating, and pyrilamine is an antihistamine that helps alleviate fluid retention and emotional symptoms.
Should not exceed recommended daily dose of acetaminophen to avoid liver damage. Contains caffeine; avoid other caffeine sources if sensitive. May cause drowsiness. Not recommended during pregnancy without medical consultation. Consult a healthcare provider before use if taking other medications or have liver disease.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy