Acetaminophen/Caffeine/Salicylamide
Acetaminophen/Caffeine/Salicylamide is a combination analgesic medication used to relieve mild to moderate pain and reduce fever. The three active ingredients work together to provide pain relief, with caffeine potentially enhancing the effectiveness of the analgesics. This combination is commonly used for headaches, toothaches, and other common pain conditions.
A combination pain reliever and fever reducer that combines two analgesics with caffeine for enhanced relief of headaches and mild pain.
Key facts at a glance
- RxNorm
- 466581
- Generic
- Acetaminophen / Caffeine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain including headaches, toothaches, muscle aches, backaches, and pain associated with menstrual cramps. Also used for reducing fever.
Acetaminophen and salicylamide work as analgesics and antipyretics by affecting the body's pain signaling and temperature regulation. Caffeine acts as an adjuvant, potentially enhancing the absorption and analgesic effects of the other ingredients and may help constrict cerebral blood vessels to relieve certain headache types.
Should not be used by individuals with liver disease, those allergic to any ingredients, or those on blood thinners without medical consultation. Avoid alcohol while taking this medication as it increases liver risk, particularly from acetaminophen. Do not exceed recommended doses or use for prolonged periods without medical advice.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy