Acetaminophen/Caffeine/Salicylic Acid
This combination medication brings together three active ingredients to provide relief from pain and headaches. Acetaminophen works centrally to reduce pain perception and fever, caffeine helps constrict blood vessels and can enhance the effectiveness of other pain relievers, and salicylic acid provides anti-inflammatory action. Together, these ingredients target multiple pathways involved in headache and general pain symptoms.
A triple-action pain reliever combining acetaminophen, caffeine, and salicylic acid for headache and general pain relief.
Key facts at a glance
- RxNorm
- 1007815
- Generic
- Acetaminophen / Caffeine / Salicylic Acid
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves minor aches and pains associated with headaches, migraines, tension headaches, toothaches, muscle aches, and menstrual cramps. Commonly used when over-the-counter single-ingredient analgesics have not provided sufficient relief.
Acetaminophen reduces pain signals in the central nervous system and helps reduce fever. Caffeine acts as a mild stimulant and may enhance pain relief by constricting blood vessels and improving the absorption of other pain relievers. Salicylic acid provides anti-inflammatory effects by inhibiting prostaglandin synthesis, reducing swelling and pain at the source.
Should not be used by individuals allergic to any of the ingredients, salicylates, or NSAIDs. Avoid in children and teenagers recovering from viral infections due to Reye's syndrome risk associated with salicylates. Consult a healthcare provider before use if pregnant, nursing, or taking blood thinners. Do not exceed recommended dose to avoid liver damage from acetaminophen or stomach irritation from salicylates.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy