Acetaminophen/Chlormezanone
Acetaminophen/Chlormezanone is a combination medication pairing an analgesic with a muscle relaxant. This combination was used to treat painful conditions involving muscle tension, such as musculoskeletal pain and certain types of headaches.
A combination analgesic and muscle relaxant for treating pain associated with muscle tension.
Key facts at a glance
- RxNorm
- 392511
- Generic
- Acetaminophen / Chlormezanone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for acute musculoskeletal pain, tension headaches, and painful conditions involving muscle spasm or tension. The combination targets both the pain sensation and the underlying muscle tightness.
Acetaminophen provides analgesic and antipyretic effects by inhibiting prostaglandin synthesis in the central nervous system. Chlormezanone acts as a centrally-acting muscle relaxant, likely affecting GABAergic neurotransmission to reduce muscle tension and anxiety associated with pain.
This medication has been discontinued or withdrawn in many countries due to safety concerns with chlormezanone, including severe cutaneous adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) and hepatotoxicity. Not currently available in most markets including the United States. Patients should consult current regional availability and approved alternatives.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy