Acetaminophen/Chlorpheniramine
Acetaminophen/Chlorpheniramine is a combination medication that provides relief from pain, fever, and allergy/cold symptoms such as runny nose, sneezing, and itchy, watery eyes. Acetaminophen works as an analgesic and fever reducer, while chlorpheniramine is an antihistamine that helps control allergic reactions and can cause drowsiness. This combination is commonly used when someone needs relief from multiple symptoms, particularly at bedtime.
A combination analgesic-antihistamine used to treat pain, fever, and cold/allergy symptoms like sneezing and runny nose.
Key facts at a glance
- RxNorm
- 214179
- Generic
- Acetaminophen / Chlorpheniramine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to temporarily relieve symptoms associated with the common cold, influenza, hay fever, and other upper respiratory allergies, including headache, minor aches and pains, fever, runny nose, sneezing, and itchy, watery eyes.
Acetaminophen works by blocking pain signals in the brain and reducing fever through the heat-regulating center in the hypothalamus. Chlorpheniramine is a first-generation antihistamine that blocks the effects of histamine, a substance the body produces during allergic reactions, thereby reducing allergy symptoms and causing drowsiness.
This medication may cause drowsiness; avoid alcohol and operating machinery until you know how it affects you. Do not use with other acetaminophen products to avoid exceeding the maximum daily dose. Consult a healthcare provider before use if you have liver disease, glaucoma, difficulty urinating, or are pregnant or breastfeeding.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy