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Acetaminophen / Chlorpheniramine / Codeine

Published: July 27, 2026Updated: August 27, 2026

This combination medication contains an analgesic (acetaminophen), an antihistamine (chlorpheniramine), and an opioid cough suppressant (codeine). It is used to temporarily relieve symptoms of the common cold, flu, or allergies, including cough, headache, body aches, fever, runny nose, sneezing, and itchy or watery eyes.

Quick summary

A combination medication for treating cold, flu, and allergy symptoms including cough, pain, fever, and respiratory symptoms.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

RxNorm
1007569
Generic
Acetaminophen / Chlorpheniramine / Codeine
Class
multi-ingredient
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Temporarily relieves symptoms associated with the common cold, flu, or allergies, including cough, headache, body aches, fever, runny nose, sneezing, and itchy or watery eyes.

Acetaminophen reduces fever and pain; chlorpheniramine blocks histamine to relieve allergic symptoms such as runny nose and sneezing; codeine suppresses the cough reflex in the brain.

Contains an opioid (codeine) with risks of dependence, drowsiness, and respiratory depression. Avoid alcohol and other CNS depressants. Use only as directed. May cause drowsiness; use caution when driving or operating machinery. Not recommended for children due to the risk of serious breathing problems.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy