Acetaminophen / Chlorpheniramine / Codeine / Phenylephrine
This combination medication is used to temporarily relieve multiple cold and allergy symptoms including fever, body aches, headache, cough, nasal congestion, and runny nose. It combines four active ingredients that work together to address pain, fever, allergies, congestion, and cough suppression. This type of medication is typically prescribed or recommended for short-term use in adults.
A multi-symptom cold and allergy relief medication combining pain/fever relief, antihistamine, cough suppressant, and decongestant properties.
Key facts at a glance
- RxNorm
- 689579
- Generic
- Acetaminophen / Chlorpheniramine / Codeine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold and upper respiratory symptoms including fever, headache, body aches, minor pain, cough, nasal congestion, sinus congestion, runny nose, sneezing, and itchy/watery eyes associated with allergies or the common cold.
Acetaminophen reduces fever and relieves minor pain. Chlorpheniramine is an antihistamine that blocks histamine to reduce allergic symptoms like sneezing and runny nose. Codeine is an opioid that suppresses the cough reflex in the brain. Phenylephrine is a decongestant that narrows blood vessels in the nasal passages to reduce swelling and congestion.
Codeine carries risks of drowsiness, dizziness, constipation, respiratory depression, and potential dependence or addiction. Do not combine with alcohol, sedatives, or other CNS depressants. Avoid exceeding recommended doses as acetaminophen can cause severe liver damage. This medication may impair ability to drive or operate machinery. Not recommended for children due to codeine risks. Consult a healthcare provider before use, especially if taking other medications or having underlying health conditions.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy