Acetaminophen / Chlorpheniramine / Codeine / Pseudoephedrine
This combination medication addresses multiple cold and allergy symptoms simultaneously. Acetaminophen provides pain relief and fever reduction, chlorpheniramine relieves sneezing and runny nose, pseudoephedrine reduces nasal and sinus congestion, and codeine helps suppress coughing. This four-ingredient formulation is typically prescribed for adults experiencing moderate to severe upper respiratory symptoms from allergies, colds, or sinus infections.
A multi-symptom cold and allergy relief medication combining a pain reliever, antihistamine, decongestant, and cough suppressant.
Key facts at a glance
- RxNorm
- 814483
- Generic
- Acetaminophen / Chlorpheniramine / Codeine / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of symptoms associated with upper respiratory tract infections, common cold, allergic rhinitis, and sinusitis, including headache, body aches, fever, nasal congestion, sinus congestion, sneezing, runny nose, and cough.
Acetaminophen inhibits prostaglandin synthesis in the brain to reduce pain and fever; chlorpheniramine blocks H-1 histamine receptors to reduce allergic symptoms; pseudoephedrine constricts blood vessels in nasal passages to reduce swelling and congestion; codeine acts on opioid receptors in the brain to suppress cough reflex and provide mild analgesia.
Contains an opioid (codeine) with potential for dependence and drowsiness. Not recommended for children under 12 years old. Avoid alcohol and operating machinery while taking this medication. Use with caution in patients with liver disease, heart conditions, hypertension, or urinary retention. May interact with other medications including MAO inhibitors, sedatives, and antidepressants. Do not exceed recommended dose to avoid acetaminophen-induced liver damage.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy