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Acetaminophen / Chlorpheniramine / Dextromethorphan / Pseudoephedrine

Published: July 27, 2026Updated: August 27, 2026

This multi-symptom cold and flu medication combines four active ingredients to address fever, pain, congestion, cough, and runny nose. It is designed for adults and children experiencing multiple upper respiratory symptoms from colds or allergies.

Quick summary

A combination cold medication that treats fever, congestion, cough, and runny nose simultaneously.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

RxNorm
689582
Generic
Acetaminophen / Chlorpheniramine / Dextromethorphan / Pseudoephedrine
Class
multi-ingredient
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Temporary relief of symptoms associated with the common cold, flu, or allergies, including fever, headache, minor aches, nasal congestion, sinus congestion, sneezing, runny nose, and cough.

Acetaminophen reduces fever and pain; chlorpheniramine blocks histamine to relieve sneezing and runny nose; dextromethorphan suppresses the cough reflex in the brain; pseudoephedrine shrinks blood vessels in nasal passages to reduce congestion.

Do not exceed recommended dose; avoid alcohol; consult a doctor if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or breathing problems; do not use with other products containing acetaminophen; stop use and consult a doctor if symptoms worsen or persist beyond 7 days.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy