Acetaminophen / Chlorpheniramine / Diphenhydramine / Pseudoephedrine
This combination medication provides relief from multiple cold and allergy symptoms. It contains a pain reliever/fever reducer (acetaminophen), two antihistamines (chlorpheniramine and diphenhydramine), and a decongestant (pseudoephedrine). It is commonly used to temporarily treat symptoms associated with the common cold, flu, or allergies.
A multi-symptom cold and allergy relief medication combining pain/fever reduction, antihistamine action, and nasal decongestion.
Key facts at a glance
- RxNorm
- 1008893
- Generic
- Acetaminophen / Chlorpheniramine / Diphenhydramine / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms of the common cold, flu, or upper respiratory allergies including nasal congestion, sinus congestion and pressure, headache, minor aches and pains, sore throat, runny nose, sneezing, and itchy/watery eyes. May also help reduce fever.
Acetaminophen works to reduce pain and fever. Chlorpheniramine and diphenhydramine block the effects of histamine, providing relief from allergic symptoms and reducing runny nose and sneezing. Pseudoephedrine constricts blood vessels in the nasal passages, reducing swelling and congestion.
May cause drowsiness; avoid operating machinery or driving until you know how the medication affects you. Contains two antihistamines, which may increase sedation. Do not use with other acetaminophen products to avoid overdose. Consult a healthcare provider before use if you have hypertension, heart disease, thyroid disorders, diabetes, glaucoma, or urinary retention. Not recommended for use in children under 12 without medical advice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy