Acetaminophen / Chlorpheniramine / Ephedrine / Guaifenesin
This combination medication provides multi-symptom relief for colds, allergies, and sinus congestion. It contains four active ingredients that work together to reduce pain and fever, relieve nasal congestion, ease allergy symptoms, and help loosen mucus in the airways.
A combination cold and allergy medication that relieves pain, congestion, allergies, and helps clear chest congestion.
Key facts at a glance
- RxNorm
- 2178933
- Generic
- Acetaminophen / Chlorpheniramine / Ephedrine / Guaifenesin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of symptoms associated with the common cold, allergies, hay fever, and sinus infections including nasal congestion, runny nose, sneezing, itchy/watery eyes, headache, body aches, sore throat, and chest congestion.
Acetaminophen reduces pain and fever; chlorpheniramine blocks histamine to relieve allergy symptoms; ephedrine constricts blood vessels in nasal passages to reduce swelling and congestion; guaifenesin thins and loosens mucus in the airways to make breathing easier and promote clearance of chest congestion.
May cause drowsiness; avoid operating machinery or driving until you know how it affects you. Do not use with other products containing acetaminophen. Consult a healthcare provider before use if you have heart disease, high blood pressure, thyroid problems, diabetes, glaucoma, or prostate issues. Not recommended during pregnancy without medical advice.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy