Acetaminophen / Chlorpheniramine / Guaifenesin
This combination medication is used to temporarily relieve symptoms associated with the common cold, allergies, or respiratory infections. It addresses multiple symptoms including pain, fever, sneezing, runny nose, itchy/watery eyes, and chest congestion. This product combines an analgesic-antipyretic, an antihistamine, and an expectorant to provide comprehensive symptom relief.
A combination cold/allergy medicine that relieves pain, fever, congestion, sneezing, and runny nose.
Key facts at a glance
- RxNorm
- 1302427
- Generic
- Acetaminophen / Chlorpheniramine / Guaifenesin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for temporary relief of multiple symptoms including headache, muscle aches, minor arthritis pain, fever, sneezing, runny nose, itchy nose/throat, itchy/watery eyes, and chest congestion due to colds, allergies, or hay fever.
Acetaminophen works as an analgesic and fever reducer. Chlorpheniramine blocks the effects of histamine to reduce allergic symptoms like sneezing and runny nose. Guaifenesin helps loosen and thin mucus in the airways, making it easier to clear from the chest.
Avoid alcohol while taking this medication. Do not use with other products containing acetaminophen as this may increase risk of liver damage. This medication may cause drowsiness; avoid driving or operating machinery until you know how it affects you. Do not use in children under 6 years unless directed by a doctor.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy