Acetaminophen / Chlorpheniramine / Guaifenesin / Phenylpropanolamine
This combination medication contains four active ingredients that work together to relieve multiple cold and allergy symptoms. Acetaminophen reduces fever and pain, while chlorpheniramine addresses allergy symptoms such as sneezing and runny nose. Guaifenesin helps loosen chest congestion, and phenylpropanolamine relieves nasal congestion.
A multi-symptom cold and allergy relief medication combining a pain reliever, antihistamine, expectorant, and decongestant.
Key facts at a glance
- RxNorm
- 817377
- Generic
- Acetaminophen / Chlorpheniramine / Guaifenesin / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, or seasonal allergies including nasal congestion, sinus congestion, headache, minor aches and pains, fever, sneezing, runny nose, and chest congestion.
Each ingredient targets different symptoms: acetaminophen inhibits pain and fever signals in the nervous system; chlorpheniramine blocks histamine receptors to reduce allergic symptoms; guaifenesin thins and loosens mucus in the airways; and phenylpropanolamine constricts blood vessels in the nasal passages to reduce swelling and congestion.
May cause drowsiness; avoid operating machinery or driving until you know how this medication affects you. Do not use with other products containing acetaminophen as this may lead to liver damage. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or urinary problems. Not recommended for children without medical advice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy