Acetaminophen / Chlorpheniramine / Phenylephrine
This medication combines three active ingredients to address multiple cold and allergy symptoms simultaneously. Acetaminophen provides pain relief and fever reduction, chlorpheniramine is an antihistamine that alleviates sneezing and runny nose, and phenylephrine acts as a decongestant to reduce nasal stuffiness. It is commonly used by adults and children seeking relief from upper respiratory symptoms associated with colds, flu, or seasonal allergies.
A multi-symptom cold and allergy relief medication combining a pain reliever, antihistamine, and decongestant.
Key facts at a glance
- RxNorm
- 689583
- Generic
- Acetaminophen / Chlorpheniramine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats symptoms of the common cold, influenza, and allergic rhinitis including headache, body aches, mild pain, fever, runny nose, sneezing, itchy/watery eyes, and nasal congestion.
Acetaminophen inhibits pain and fever signals in the brain; chlorpheniramine blocks histamine receptors to reduce allergic-type symptoms; phenylephrine constricts blood vessels in the nasal passages to decrease swelling and congestion.
Do not combine with other products containing acetaminophen to avoid liver toxicity risk. Chlorpheniramine may cause drowsiness; avoid alcohol and operating machinery. Consult a healthcare provider if you have heart disease, high blood pressure, thyroid disorders, diabetes, glaucoma, or prostate problems. Not recommended during pregnancy without medical advice.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy