Acetaminophen / Chlorpheniramine / Phenylephrine / Pyrilamine
This multi-ingredient medication combines pain relief, antihistamines, and a decongestant to address multiple cold and allergy symptoms simultaneously. It is typically used to temporarily relieve symptoms such as fever, headache, body aches, nasal congestion, sneezing, runny nose, and itchy/watery eyes associated with the common cold, flu, or allergic rhinitis.
A combination cold, flu, and allergy relief medication that addresses pain, congestion, and allergic symptoms in one formulation.
Key facts at a glance
- RxNorm
- 689584
- Generic
- Acetaminophen / Chlorpheniramine / Phenylephrine / Pyrilamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms of the common cold, flu, and allergic rhinitis including fever, headache, minor aches and pains, nasal and sinus congestion, sneezing, runny nose, itchy nose and throat, and itchy, watery eyes.
Acetaminophen reduces fever and relieves pain. Chlorpheniramine and pyrilamine (both antihistamines) block the effects of histamine to reduce sneezing, itching, and runny nose. Phenylephrine (a nasal decongestant) constricts blood vessels in the nasal passages to reduce congestion and swelling.
Do not exceed the recommended dose, as acetaminophen can cause serious liver damage. Avoid use with alcohol or other sedating medications due to the antihistamine components. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or urinary retention. Not recommended during pregnancy without medical advice. May cause drowsiness; avoid driving or operating machinery until you know how it affects you.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy