Acetaminophen / Chlorpheniramine / Phenylephrine / Salicylamide
This combination medication provides multi-symptom relief for colds, allergies, and sinus congestion by addressing several common symptoms simultaneously. It contains an analgesic-antipyretic for pain and fever, an antihistamine for sneezing and runny nose, a decongestant for nasal congestion, and an additional analgesic component. This medication is typically used by adults and children seeking relief from multiple cold or allergy symptoms at once.
A multi-symptom cold and allergy relief medication combining pain/fever reducers with an antihistamine and decongestant.
Key facts at a glance
- RxNorm
- 689585
- Generic
- Acetaminophen / Chlorpheniramine / Phenylephrine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, allergies, hay fever, and sinus congestion including headache, fever, minor aches and pains, nasal congestion, sinus congestion, sneezing, runny nose, and itchy or watery eyes.
Acetaminophen and salicylamide work to reduce pain and fever. Chlorpheniramine blocks histamine receptors to reduce allergic symptoms like sneezing and runny nose. Phenylephrine constricts blood vessels in the nasal passages to reduce swelling and congestion.
This product contains salicylamide, a salicylate related to aspirin. Do not use if you have aspirin allergy. Avoid alcohol and other medications containing acetaminophen. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid disease, diabetes, glaucoma, or breathing problems. May cause drowsiness; avoid driving until you know how the medication affects you.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy