Acetaminophen / Chlorpheniramine / Phenylpropanolamine
This combination medication is used to temporarily relieve symptoms associated with colds, allergies, and hay fever. It contains a pain reliever/fever reducer (acetaminophen), an antihistamine (chlorpheniramine), and a decongestant (phenylpropanolamine) to address multiple symptoms including congestion, sneezing, runny nose, headache, and minor aches.
A multi-symptom cold and allergy relief medication combining pain/fever reduction, antihistamine, and decongestant properties.
Key facts at a glance
- RxNorm
- 689762
- Generic
- Acetaminophen / Chlorpheniramine / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves nasal congestion, sinus congestion and pressure, headache, minor aches and pains, runny nose, sneezing, and itchy/watery eyes due to common cold, hay fever, or other upper respiratory allergies.
Acetaminophen reduces fever and pain; chlorpheniramine blocks histamine to reduce allergic symptoms like sneezing and itching; phenylpropanolamine constricts blood vessels in nasal passages to reduce swelling and congestion.
May cause drowsiness; avoid alcohol and operating machinery until you know how it affects you. Do not use with other acetaminophen products to avoid overdose. Consult a healthcare provider if you have high blood pressure, heart disease, thyroid disease, diabetes, glaucoma, or difficulty urinating. Not recommended for use in children under 6 years of age without medical advice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy