Acetaminophen / Chlorpheniramine / Phenylpropanolamine / Phenyltoloxamine
This combination medication contains four active ingredients that work together to provide relief from multiple cold and allergy symptoms. Acetaminophen acts as a pain reliever and fever reducer, while the two antihistamines (chlorpheniramine and phenyltoloxamine) help reduce allergic symptoms like sneezing and runny nose. Phenylpropanolamine serves as a decongestant to relieve nasal congestion.
A multi-symptom cold and allergy relief medication combining pain/fever reduction with antihistamine and decongestant properties.
Key facts at a glance
- RxNorm
- 817322
- Generic
- Acetaminophen / Chlorpheniramine / Phenylpropanolamine / Phenyltoloxamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, hay fever, and other upper respiratory allergies including headache, fever, minor aches, sneezing, runny nose, itchy/watery eyes, and nasal/sinus congestion.
Acetaminophen inhibits pain and fever signals in the nervous system. Chlorpheniramine and phenyltoloxamine are antihistamines that block histamine receptors, reducing allergic symptoms. Phenylpropanolamine is a sympathomimetic decongestant that constricts blood vessels in the nasal passages, reducing swelling and congestion.
Contains acetaminophen; avoid alcohol and do not exceed recommended doses to prevent liver damage. May cause drowsiness; avoid driving or operating machinery. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or urinary problems. Not recommended for children under 6 years without medical advice.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy