Acetaminophen / Chlorpheniramine / Phenylpropanolamine / Salicylamide
This is a multi-symptom cold and flu medication combining four active ingredients to relieve fever, pain, nasal congestion, sneezing, and runny nose. The combination includes a pain reliever/fever reducer (acetaminophen), an antihistamine (chlorpheniramine), a decongestant (phenylpropanolamine), and a salicylate pain reliever (salicylamide). It is typically used by adults and children experiencing multiple cold or allergy symptoms.
Combination cold/flu medication that treats fever, pain, congestion, and allergic symptoms together.
Key facts at a glance
- RxNorm
- 689764
- Generic
- Acetaminophen / Chlorpheniramine / Phenylpropanolamine / Salicylamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold and flu symptoms including fever, headache, body aches, nasal congestion, sneezing, runny nose, and minor allergic reactions. May also be used for sinus pressure and hay fever symptoms.
Acetaminophen reduces fever and pain; chlorpheniramine blocks histamine to relieve sneezing and runny nose; phenylpropanolamine constricts blood vessels in nasal passages to reduce congestion; salicylamide provides additional analgesic and anti-inflammatory effects.
May cause drowsiness; avoid alcohol and operating machinery. Do not use with other products containing acetaminophen or salicylates. Consult a doctor if you have high blood pressure, heart disease, thyroid problems, glaucoma, or urinary problems. Not recommended during pregnancy without medical advice. Keep out of reach of children.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy