Acetaminophen / Chlorzoxazone
This medication combines acetaminophen, an analgesic that relieves pain and reduces fever, with chlorzoxazone, a muscle relaxant that helps ease tension and spasms in muscles. It is prescribed to treat painful musculoskeletal conditions where both pain relief and muscle relaxation are needed, such as strains, sprains, and other muscle injuries.
A combination analgesic and muscle relaxant used to treat pain and discomfort from muscle spasms and musculoskeletal injuries.
Key facts at a glance
- RxNorm
- 494309
- Generic
- Acetaminophen / Chlorzoxazone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of acute, painful musculoskeletal conditions including muscle strains, sprains, and spasms; often used following injuries or in conditions causing muscle tension and associated pain
Acetaminophen works by inhibiting pain signals in the central nervous system and may reduce fever; chlorzoxazone acts on the brainstem and spinal cord to suppress reflexes that contribute to muscle spasms, thereby reducing muscle tension and discomfort
Should be used with caution in patients with liver disease due to the acetaminophen component; may cause drowsiness or dizziness; avoid alcohol during treatment; not recommended for prolonged use; generally not suitable for chronic muscle spasm conditions
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy