Acetaminophen / Clemastine / Phenylpropanolamine
This multi-ingredient medication combines an analgesic-antipyretic (acetaminophen), an antihistamine (clemastine), and a decongestant (phenylpropanolamine) to address multiple cold and allergy symptoms simultaneously. It is typically used to temporarily relieve nasal congestion, sneezing, runny nose, itchy/watery eyes, headache, minor aches, and fever associated with upper respiratory infections or allergic reactions.
A combination cold and allergy medication that treats congestion, allergic symptoms, pain, and fever together.
Key facts at a glance
- RxNorm
- 1007085
- Generic
- Acetaminophen / Clemastine / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold symptoms (nasal congestion, sinus pressure, headache, body aches, fever) and allergic rhinitis symptoms (sneezing, runny nose, itchy nose/eyes, watery eyes).
Acetaminophen reduces pain and fever; clemastine blocks histamine to relieve allergic symptoms; phenylpropanolamine constricts blood vessels in nasal passages to reduce swelling and congestion.
May cause drowsiness; avoid alcohol and operating machinery until known. Not for use in children under 12 without medical advice. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid disorders, diabetes, glaucoma, or urinary problems. Do not exceed recommended doses.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy