Acetaminophen / Clemastine / Pseudoephedrine
This combination medication contains three active ingredients that work together to relieve multiple symptoms of colds, allergies, and sinus congestion. Acetaminophen reduces fever and pain, clemastine provides antihistamine effects to address runny nose and sneezing, while pseudoephedrine acts as a decongestant to relieve nasal stuffiness. This makes it a comprehensive option for individuals experiencing overlapping cold, allergy, or sinus symptoms.
A combination cold/allergy medication that addresses pain, fever, congestion, runny nose, and sneezing through three complementary active ingredients.
Key facts at a glance
- RxNorm
- 1008295
- Generic
- Acetaminophen / Clemastine / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold symptoms, allergic rhinitis, and sinus congestion including headache, fever, body aches, runny nose, sneezing, itchy/watery eyes, and nasal or sinus congestion.
Acetaminophen inhibits pain and fever signals in the brain; clemastine blocks histamine receptors to reduce allergic symptoms; pseudoephedrine constricts blood vessels in nasal passages to reduce swelling and congestion.
Do not exceed recommended dose to avoid liver damage from acetaminophen. Pseudoephedrine may cause excitability, insomnia, or raise blood pressure. Avoid if taking other acetaminophen products. Consult a doctor if symptoms persist beyond 7 days, if pregnant, nursing, or have conditions like heart disease, high blood pressure, thyroid disorders, or glaucoma.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy