Acetaminophen / Codeine / Guaifenesin / Phenylephrine
This combination medication contains four active ingredients that work together to relieve multiple symptoms of cold, flu, and respiratory infections. Acetaminophen provides pain relief and fever reduction, codeine addresses coughing and additional pain relief, guaifenesin helps loosen mucus in the airways, and phenylephrine reduces nasal congestion. This medication is typically prescribed when patients experience a combination of fever, pain, cough, chest congestion, and nasal congestion.
A multi-symptom cold and flu medication that relieves pain, fever, cough, congestion, and chest congestion through a combination of four active ingredients.
Key facts at a glance
- RxNorm
- 1008871
- Generic
- Acetaminophen / Codeine / Guaifenesin / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to temporarily relieve symptoms associated with the common cold, flu, and upper respiratory infections, including fever, headache, body aches, sore throat, cough, chest congestion, and nasal congestion.
Each ingredient works through a different mechanism: acetaminophen inhibits pain and fever signals in the nervous system; codeine acts on the brain's cough reflex to suppress coughing; guaifenesin thins and loosens mucus in the lungs and airways; and phenylephrine constricts blood vessels in the nasal passages to reduce swelling and congestion.
This medication contains codeine, an opioid that carries risks of dependence, drowsiness, and respiratory depression. It should not be combined with alcohol or other CNS depressants. Patients should avoid driving or operating machinery until they know how this medication affects them. Codeine is not recommended for children under 12 years old or for adolescents after certain surgeries. Due to the acetaminophen component, patients with liver disease should use caution. Always follow prescribed dosages carefully and consult a healthcare provider before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy