Acetaminophen / Codeine / Guaifenesin / Pseudoephedrine
This combination medication is used to temporarily relieve multiple symptoms of colds, flu, and respiratory infections, including headache, body aches, fever, cough, chest congestion, and nasal congestion. It combines four active ingredients that work together to reduce pain and fever, suppress coughing, loosen mucus, and relieve sinus pressure. This medication is typically prescribed when a patient has several overlapping symptoms that warrant a multi-symptom approach.
A multi-ingredient cold medication that combines pain/fever relief, cough suppression, mucus loosening, and congestion relief for symptomatic treatment of respiratory illnesses.
Key facts at a glance
- RxNorm
- 1007572
- Generic
- Acetaminophen / Codeine / Guaifenesin / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of multiple symptoms associated with colds, flu, and upper respiratory infections, including headache, body aches, minor pain, fever, cough, chest congestion, and nasal congestion. Guaifenesin specifically helps loosen phlegm and thin bronchial secretions.
Each ingredient works through a different mechanism: Acetaminophen reduces pain and fever by affecting the hypothalamus; Codeine suppresses the cough reflex in the brain; Guaifenesin loosens and thins mucus in the airways by increasing hydration; Pseudoephedrine constricts blood vessels in the nasal passages to reduce swelling and congestion.
Contains codeine, an opioid that carries risks of dependence, sedation, and respiratory depression. Not recommended for children under 12 years old. May cause drowsiness; avoid alcohol and operating machinery until aware of effects. Should not be used by those with certain medical conditions (severe hypertension, breathing problems) or who are taking MAO inhibitors. Do not exceed recommended doses to avoid liver damage from acetaminophen.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy