Acetaminophen / Codeine / Magnesium Salicylate / Phenyltoloxamine
This is a combination analgesic medication that works through multiple mechanisms to relieve moderate to severe pain. It combines an opioid (codeine), two non-opioid pain relievers (acetaminophen and a salicylate), and an antihistamine (phenyltoloxamine) to address both pain and associated symptoms. This type of combination may be prescribed when single-ingredient analgesics are insufficient.
A multi-ingredient pain medication combining opioid and non-opioid analgesics with an antihistamine for enhanced pain relief.
Key facts at a glance
- RxNorm
- 1008554
- Generic
- Acetaminophen / Codeine / Magnesium Salicylate / Phenyltoloxamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for the management of moderate to moderately severe pain that requires multiple analgesic mechanisms. May be prescribed when over-the-counter pain relievers alone provide inadequate relief, and when the combination approach is deemed appropriate by a healthcare provider.
Codeine acts on opioid receptors in the brain to alter pain perception. Acetaminophen and magnesium salicylate reduce pain and inflammation through different mechanisms (affecting prostaglandin production and central nervous system pathways). Phenyltoloxamine, an antihistamine, may enhance analgesic effects and help relieve associated symptoms like allergic reactions or sinus pressure.
Contains codeine, an opioid with risk of dependence, sedation, and respiratory depression. Should not be combined with alcohol or other CNS depressants. Caution advised in patients with liver disease (due to acetaminophen and salicylate components), respiratory conditions, or history of substance abuse. Use during pregnancy and breastfeeding requires careful evaluation of risks versus benefits.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy