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Acetaminophen / Dexchlorpheniramine / Pseudoephedrine

Published: July 27, 2026Updated: August 27, 2026

This combination medication contains three active ingredients that work together to provide relief from multiple cold and allergy symptoms. Acetaminophen reduces fever and alleviates minor aches and pains, while dexchlorpheniramine addresses allergic symptoms such as runny nose, sneezing, and watery eyes. Pseudoephedrine acts as a decongestant to help relieve nasal and sinus congestion.

Quick summary

A multi-symptom cold and allergy relief medication combining a pain reliever, antihistamine, and decongestant.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

RxNorm
1008706
Generic
Acetaminophen / Dexchlorpheniramine / Pseudoephedrine
Class
multi-ingredient
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

This medication is typically used to temporarily relieve symptoms associated with the common cold, flu, or allergic rhinitis, including fever, headache, minor body aches, sneezing, runny nose, itchy/watery eyes, and nasal/sinus congestion.

Acetaminophen works as an analgesic and antipyretic in the brain to reduce pain perception and fever. Dexchlorpheniramine is a first-generation antihistamine that blocks histamine receptors, reducing allergic symptoms. Pseudoephedrine is a sympathomimetic decongestant that constricts blood vessels in the nasal passages, reducing swelling and congestion.

This medication may cause drowsiness; avoid operating machinery or driving until you know how it affects you. Do not use with alcohol or other sedatives. Those with certain medical conditions (heart disease, hypertension, thyroid disorders, glaucoma, enlarged prostate) should consult a healthcare provider before use. Do not exceed recommended doses, as acetaminophen can cause liver damage. Pseudoephedrine availability may be restricted in some regions due to its use in illicit drug synthesis.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy