Acetaminophen / Dextromethorphan / Diphenhydramine / Guaifenesin / Phenylephrine
This multi-symptom cold and flu medication combines five active ingredients to provide comprehensive relief from respiratory infections. It addresses pain/fever, cough, congestion, runny nose, and chest congestion simultaneously. This combination makes it suitable for people experiencing multiple cold or flu symptoms at once.
A comprehensive cold and flu remedy that treats pain, fever, cough, congestion, and mucus in a single product.
Key facts at a glance
- RxNorm
- 1664630
- Generic
- Acetaminophen / Dextromethorphan / Diphenhydramine / Guaifenesin / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, hay fever, and other respiratory allergies including headache, minor aches and pains, fever, sore throat, cough due to minor throat irritation, nasal congestion, sinus congestion and pressure, runny nose, sneezing, and chest congestion.
Acetaminophen reduces fever and pain; dextromethorphan suppresses the cough reflex in the brain; diphenhydramine blocks histamine to reduce runny nose and sneezing; guaifenesin thins and loosens mucus in the airways; phenylephrine constricts blood vessels in the nasal passages to reduce congestion and swelling.
Do not use with other products containing acetaminophen as this may cause liver damage. Avoid alcohol. May cause drowsiness due to diphenhydramine. Do not use if taking an MAOI or within 14 days of stopping one. Consult a doctor before use if you have heart disease, high blood pressure, thyroid disease, diabetes, glaucoma, enlarged prostate, or breathing problems.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy