Acetaminophen / Dextromethorphan / Diphenhydramine / Phenylephrine
This combination medication provides multi-symptom relief for cold, flu, and allergy symptoms. It addresses pain, fever, cough, nasal congestion, and sneezing through four complementary ingredients. This product is typically used by adults and children seeking relief from multiple respiratory symptoms at once.
A combination cold/flu medication that relieves pain, fever, cough, congestion, and runny nose.
Key facts at a glance
- RxNorm
- 1008802
- Generic
- Acetaminophen / Dextromethorphan / Diphenhydramine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, or upper respiratory allergies including: headache, minor aches and pains, fever, sore throat, cough due to minor throat irritation, nasal congestion, sinus congestion and pressure, runny nose, and sneezing.
Acetaminophen works as an analgesic and antipyretic to reduce pain and fever. Dextromethorphan suppresses cough by acting on the cough center in the brain. Diphenhydramine, a first-generation antihistamine, blocks histamine to reduce runny nose and sneezing, and may also cause drowsiness. Phenylephrine acts as a decongestant by constricting blood vessels in the nasal passages to reduce swelling and congestion.
May cause drowsiness; avoid alcohol and operating machinery until aware of effects. Do not use with other products containing acetaminophen. Consult a healthcare provider before use if you have high blood pressure, thyroid disease, diabetes, glaucoma, breathing problems, or are pregnant/nursing. Not recommended for children under certain ages without medical advice. Do not exceed recommended doses.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy