Acetaminophen / Dextromethorphan / Diphenhydramine / Pseudoephedrine
This combination medication provides multi-symptom relief for cold and flu symptoms by addressing fever, pain, cough, nasal congestion, and allergies simultaneously. The acetaminophen component reduces fever and pain, while dextromethorphan suppresses coughing, diphenhydramine relieves allergy symptoms and promotes rest, and pseudoephedrine reduces nasal congestion. It is typically used by adults and children seeking relief from multiple cold symptoms when rest and comfort are priorities.
A multi-symptom cold and flu remedy combining pain/fever relief, cough suppression, allergy treatment, and nasal decongestion in one medication.
Key facts at a glance
- RxNorm
- 466566
- Generic
- Acetaminophen / Dextromethorphan / Diphenhydramine / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, flu, hay fever, and other upper respiratory allergies including fever, headache, sore throat, minor aches and pains, cough, nasal congestion, sinus congestion, runny nose, sneezing, and itchy/watery eyes.
Acetaminophen inhibits pain and fever signals in the nervous system. Dextromethorphan acts on the cough center in the brain to suppress coughing. Diphenhydramine blocks histamine receptors to reduce allergic symptoms and has sedating effects. Pseudoephedrine constricts blood vessels in the nasal passages to reduce swelling and congestion.
May cause drowsiness; avoid operating machinery or driving until aware of effects. Do not use with alcohol or other sedatives. Contains acetaminophen; follow dosing instructions carefully to avoid liver damage. Not recommended for use before or after certain surgeries. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications. Not suitable for children under certain ages without medical guidance.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy