Acetaminophen / Dextromethorphan / Doxylamine
This combination medication provides relief from multiple cold and flu symptoms by combining a pain reliever/fever reducer, a cough suppressant, and an antihistamine. It is typically used to temporarily alleviate symptoms such as cough, body aches, headache, fever, runny nose, and sneezing.
A multi-symptom cold and flu medication that relieves cough, pain, fever, and nasal symptoms in adults and children.
Key facts at a glance
- RxNorm
- 705258
- Generic
- Acetaminophen / Dextromethorphan / Doxylamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves common cold and flu symptoms including cough, sore throat, headache, minor aches and pains, fever, runny nose, sneezing, and sinus congestion.
Acetaminophen reduces fever and relieves pain; dextromethorphan suppresses the cough reflex in the brain; and doxylamine blocks histamine to reduce runny nose and sneezing while promoting drowsiness.
Avoid alcohol and other CNS depressants while taking this medication. Do not exceed recommended dose to prevent serious liver damage from acetaminophen. The antihistamine component causes drowsiness. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy