Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine
This combination medication provides multi-symptom relief for cold and flu symptoms by addressing fever, pain, cough, nasal congestion, and allergy-like symptoms. It is typically used by adults to manage symptoms of upper respiratory infections including the common cold, sinusitis, and influenza.
A cold and flu symptom relief medication combining pain/fever reduction, cough suppression, antihistamine, and decongestant effects.
Key facts at a glance
- RxNorm
- 1008701
- Generic
- Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of multiple cold and flu symptoms including fever, headache, minor aches and pains, cough due to minor throat and bronchial irritation, runny nose, sneezing, itchy nose or throat, and nasal/sinus congestion.
Acetaminophen reduces fever and pain; dextromethorphan suppresses the cough reflex in the brain; doxylamine blocks histamine to reduce sneezing and runny nose; phenylephrine constricts blood vessels in the nasal passages to reduce congestion.
Contains acetaminophen - do not use with other acetaminophen products to avoid liver damage. May cause drowsiness; avoid alcohol and operating machinery. Do not use if taking MAO inhibitors or within 2 weeks of stopping them. Consult a healthcare provider before use if you have heart disease, high blood pressure, thyroid disorders, diabetes, glaucoma, or breathing problems. Not for use in children under 12 years.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy