Acetaminophen / Dextromethorphan / Doxylamine / Pseudoephedrine
This medication combines four active ingredients to provide multi-symptom relief for cold, flu, and allergy symptoms. Acetaminophen addresses pain and fever, while dextromethorphan suppresses coughing, doxylamine helps with sneezing and runny nose, and pseudoephedrine relieves nasal congestion. This combination is typically used when multiple symptoms are present and need simultaneous relief.
A multi-symptom cold and flu medication combining a pain reliever, cough suppressant, antihistamine, and decongestant.
Key facts at a glance
- RxNorm
- 466524
- Generic
- Acetaminophen / Dextromethorphan / Doxylamine / Pseudoephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves common cold and flu symptoms including headache, fever, minor aches, sore throat, nasal congestion, sinus congestion, cough, and sneezing. Also useful for allergy symptoms such as runny nose and itchy eyes.
Acetaminophen inhibits prostaglandin production to reduce pain and fever. Dextromethorphan suppresses the cough reflex in the brain. Doxylamine blocks histamine receptors to reduce allergic symptoms. Pseudoephedrine constricts blood vessels in nasal passages to decrease swelling and congestion.
Do not use with other acetaminophen products to avoid liver damage. Consult a doctor before use if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or breathing problems. Avoid alcohol. May cause drowsiness. Do not use if taking MAOI inhibitors or within 2 weeks of stopping them. Not recommended for children under 12 without medical advice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy