Acetaminophen / Dextromethorphan / Guaifenesin
This combination medication provides multi-symptom relief for cold, flu, and respiratory infections by addressing fever and minor aches (acetaminophen), suppressing dry or tickling coughs (dextromethorphan), and helping to loosen and clear chest congestion (guaifenesin). It is commonly used by adults and children experiencing overlapping symptoms of pain, cough, and congestion.
A cold and flu symptom relief medication combining a pain reliever, cough suppressant, and expectorant.
Key facts at a glance
- RxNorm
- 689775
- Generic
- Acetaminophen / Dextromethorphan / Guaifenesin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats common cold symptoms, flu symptoms, and upper respiratory infections including fever, headache, minor body aches, dry or nagging cough, and chest congestion with mucus buildup.
Acetaminophen reduces fever and relieves minor pain by affecting the brain's temperature regulation and pain signaling. Dextromethorphan suppresses cough signals in the brain's cough center. Guaifenesin thins and loosens mucus in the airways, making it easier to clear through coughing.
Do not combine with other acetaminophen products to avoid overdose. Avoid alcohol during use. Not recommended for persistent cough due to smoking, asthma, or emphysema without medical advice. Consult a healthcare provider before use if taking other medications, have liver disease, or are pregnant or breastfeeding.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy