Acetaminophen / Dextromethorphan / Guaifenesin / Phenylpropanolamine
This multi-ingredient medication combines four active ingredients to provide comprehensive relief from cold and flu symptoms. It addresses fever and pain, suppresses cough, loosens chest congestion, and relieves nasal congestion simultaneously. The medication is typically used by adults experiencing multiple overlapping cold or flu symptoms.
A combination cold and flu medication that relieves fever, pain, cough, nasal congestion, and chest congestion.
Key facts at a glance
- RxNorm
- 689777
- Generic
- Acetaminophen / Dextromethorphan / Guaifenesin / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats multiple cold and flu symptoms including fever, headache, body aches, nasal and sinus congestion, chest congestion with mucus, and cough.
Acetaminophen reduces fever and relieves pain; Dextromethorphan suppresses the cough reflex in the brain; Guaifenesin thins and loosens mucus in the airways to make coughs more productive; Phenylpropanolamine constricts blood vessels in the nasal passages to reduce swelling and congestion.
Do not exceed the recommended daily dose of acetaminophen to avoid liver damage. Avoid alcohol during treatment. Not recommended for children. Consult a healthcare provider if you have high blood pressure, heart disease, thyroid problems, diabetes, or are taking antidepressants. Stop use and seek medical attention if symptoms worsen or persist beyond 7 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy