Acetaminophen / Dextromethorphan / Phenylephrine / Pyrilamine
This multi-ingredient medication combines four active ingredients to provide relief from multiple cold and allergy symptoms. It is typically used to temporarily alleviate fever, headache, body aches, cough, nasal congestion, and sneezing associated with upper respiratory conditions.
A combination cold and allergy relief medication addressing fever, pain, cough, congestion, and allergic symptoms.
Key facts at a glance
- RxNorm
- 689779
- Generic
- Acetaminophen / Dextromethorphan / Phenylephrine / Pyrilamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms of the common cold, flu, hay fever, and other upper respiratory allergies including fever, headache, minor aches and pains, cough due to minor throat and bronchial irritation, nasal congestion, sneezing, and itchy, watery eyes.
Acetaminophen reduces fever and relieves pain. Dextromethorphan suppresses the cough reflex in the brain. Phenylephrine shrinks blood vessels in the nasal passages to reduce congestion. Pyrilamine blocks histamine to relieve allergic symptoms like sneezing and runny nose.
Do not use with other products containing acetaminophen. Avoid alcohol. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or breathing problems. Do not use if taking an MAOI or within 14 days of stopping one. May cause drowsiness.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy