Acetaminophen / Dextromethorphan / Phenylpropanolamine
This combination medication provides multi-symptom relief for colds and upper respiratory infections by addressing pain, fever, cough, and nasal congestion simultaneously. Each ingredient targets a different symptom set, making it useful when patients experience multiple cold-related complaints. It is typically used for temporary relief of common cold symptoms.
A combination cold medication that relieves pain, fever, cough, and nasal congestion through three different active ingredients.
Key facts at a glance
- RxNorm
- 689780
- Generic
- Acetaminophen / Dextromethorphan / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold symptoms including headache, minor aches and pains, fever, sore throat, cough due to minor throat irritation, and nasal congestion
Acetaminophen reduces pain and fever by inhibiting prostaglandin synthesis in the brain; dextromethorphan suppresses the cough reflex by acting on the medulla's cough center; phenylpropanolamine relieves nasal congestion by constricting blood vessels in the nasal passages through alpha-adrenergic stimulation
Contains acetaminophen - do not exceed maximum daily dose to avoid liver damage. Phenylpropanolamine has been withdrawn from the market in many countries due to stroke risk and is contraindicated in patients with cardiovascular disease, hypertension, or those taking MAO inhibitors. Consult a healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy