Acetaminophen / Dichloralphenazone / Isometheptene
This is a combination medication used to treat migraine and tension headaches. It contains three ingredients that work together: acetaminophen for pain relief, dichloralphenazone for muscle relaxation and calming effects, and isometheptene to narrow blood vessels in the head. This medication is typically prescribed for adults experiencing moderate to severe headache pain.
A three-ingredient combination medication for treating migraine and tension headaches by combining pain relief, muscle relaxation, and vasoconstriction.
Key facts at a glance
- RxNorm
- 214153
- Generic
- Acetaminophen / Dichloralphenazone / Isometheptene
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for acute treatment of migraine headaches and tension-type headaches in adults. It is not intended for preventive use or for treating other types of pain.
The three components work synergistically: acetaminophen provides analgesic and antipyretic effects; dichloralphenazone acts as a mild sedative and muscle relaxant; isometheptene causes vasoconstriction of cranial blood vessels, which may help relieve migraine-related vessel dilation.
Contraindicated with MAO inhibitors and in patients with glaucoma, severe hypertension, or cardiovascular disease. Risk of medication-overuse headaches with prolonged use. Should not be used during pregnancy without medical supervision. Avoid alcohol and sedatives while taking this medication.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy