Acetaminophen / Diphenhydramine
Acetaminophen/Diphenhydramine is a combination medication that provides pain relief and fever reduction (from acetaminophen) along with antihistamine effects and sedation (from diphenhydramine). It is commonly used for nighttime relief of minor aches, pain, fever, and allergy symptoms, often serving as a sleep aid due to its sedating properties.
A combination analgesic-antihistamine used for nighttime pain relief and sleep support.
Key facts at a glance
- RxNorm
- 214181
- Generic
- Acetaminophen / Diphenhydramine
- Class
- multi-ingredient
- Brands
- Percogesic Reformulated Jan 2011, Panadol PM, Acetadryl, Excedrin PM, Legatrin PM, Tylenol PM, Unisom with Pain Relief
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of minor aches, pains, headaches, fever, and allergy symptoms such as runny nose or sneezing, particularly when nighttime sedation is desired.
Acetaminophen works in the brain to reduce pain signals and lower body temperature, while diphenhydramine blocks histamine receptors and produces drowsiness by acting on the central nervous system.
May cause drowsiness; avoid alcohol and operating machinery. Do not exceed recommended dose as acetaminophen can cause liver damage. Not recommended for use in children under 12 without medical advice. Consult a healthcare provider if symptoms persist beyond 10 days or for fever lasting more than 3 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy