Acetaminophen / Diphenhydramine / Guaifenesin / Phenylephrine
This multi-symptom cold and flu medication combines four active ingredients to address multiple symptoms simultaneously. Acetaminophen provides pain and fever relief, while diphenhydramine helps with allergic symptoms and runny nose. Guaifenesin loosens chest congestion, and phenylephrine reduces nasal congestion, making this suitable for people experiencing several cold or flu symptoms at once.
A combination cold/flu medication that treats pain, fever, congestion, and cough through four complementary active ingredients.
Key facts at a glance
- RxNorm
- 819002
- Generic
- Acetaminophen / Diphenhydramine / Guaifenesin / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves common cold and flu symptoms including headache, minor aches and pains, fever, sore throat, nasal congestion, sinus congestion, runny nose, sneezing, and chest congestion.
Acetaminophen reduces fever and pain; diphenhydramine blocks histamine to reduce sneezing and runny nose; guaifenesin thins and loosens mucus in the airways; phenylephrine constricts blood vessels in the nasal passages to reduce swelling and congestion.
May cause drowsiness due to diphenhydramine. Avoid alcohol and other sedating medications. Do not use with other products containing acetaminophen. Consult a healthcare provider if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or urinary problems. Not recommended for children under certain ages without medical advice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy