Acetaminophen / Diphenhydramine / Phenylephrine
This combination medication contains three active ingredients that work together to relieve multiple symptoms of colds, allergies, and sinus congestion. Acetaminophen reduces pain and fever, diphenhydramine addresses allergy symptoms such as sneezing and itchy eyes, while phenylephrine helps relieve nasal congestion. This multi-symptom formula is commonly used when patients experience overlapping cold and allergy symptoms.
A combination of pain/fever reducer, antihistamine, and decongestant used to treat multiple cold and allergy symptoms simultaneously.
Key facts at a glance
- RxNorm
- 689785
- Generic
- Acetaminophen / Diphenhydramine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with the common cold, allergies, hay fever, and sinus congestion including headache, fever, minor aches and pains, sneezing, runny nose, itchy nose and throat, and nasal/sinus congestion.
Acetaminophen inhibits the production of prostaglandins in the brain to reduce pain and fever. Diphenhydramine is an antihistamine that blocks histamine H1 receptors to reduce allergic symptoms. Phenylephrine is a decongestant that constricts blood vessels in the nasal passages to reduce swelling and congestion.
May cause drowsiness; avoid alcohol and operating machinery until you know how the medication affects you. Do not use with other products containing acetaminophen to avoid overdose. Consult a healthcare provider before use if you have high blood pressure, heart disease, thyroid problems, diabetes, glaucoma, or difficulty urinating due to enlarged prostate. Not recommended for children under 12 without medical advice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy