Acetaminophen / Diphenhydramine / Phenylpropanolamine
This combination medication contains three active ingredients that work together to relieve multiple cold and allergy symptoms. Acetaminophen provides pain relief and reduces fever, diphenhydramine addresses allergy symptoms and can promote drowsiness, while phenylpropanolamine acts as a decongestant to relieve nasal stuffiness. This medication is typically used by adults seeking relief from symptoms such as headache, fever, nasal congestion, and minor aches associated with colds or allergic reactions.
A multi-symptom cold and allergy relief medication combining pain/fever reduction, antihistamine effects, and nasal decongestion.
Key facts at a glance
- RxNorm
- 813715
- Generic
- Acetaminophen / Diphenhydramine / Phenylpropanolamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of common cold and allergy symptoms including headache, fever, minor aches and pains, nasal congestion, sinus pressure, runny nose, sneezing, and itchy/watery eyes. May also be used when sleep is desired during illness due to its sedating properties.
Acetaminophen works by affecting the body's temperature regulation and pain perception. Diphenhydramine blocks histamine receptors, reducing allergic symptoms and causing drowsiness. Phenylpropanolamine constricts blood vessels in the nasal passages, reducing swelling and congestion.
May cause drowsiness; avoid alcohol and operating machinery until you know how it affects you. Do not use with other products containing acetaminophen to avoid overdose. Not recommended for children under 12 without medical advice. Consult a healthcare provider if you have high blood pressure, heart disease, thyroid disorders, or are taking other medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy