Acetaminophen / Domperidone
Acetaminophen/Domperidone is a combination medication that pairs an analgesic with an antiemetic. Acetaminophen relieves pain and reduces fever, while domperidone helps control nausea and vomiting. This combination is commonly used to treat conditions like migraines or tension headaches that are accompanied by nausea.
A pain reliever and anti-nausea medication combined to treat headaches or pain with associated nausea and vomiting.
Key facts at a glance
- RxNorm
- 1009123
- Generic
- Acetaminophen / Domperidone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to treat headaches, migraines, and other painful conditions when accompanied by nausea or vomiting. It may also be prescribed for general pain relief in patients who experience nausea as a symptom.
Acetaminophen works by inhibiting cyclooxygenase (COX) enzymes in the brain, reducing pain signals and fever. Domperidone blocks dopamine receptors in the chemoreceptor trigger zone of the brain, which helps prevent nausea and vomiting.
Do not exceed recommended doses of acetaminophen as it can cause liver damage. Domperidone may rarely cause heart rhythm abnormalities, particularly in patients with existing heart conditions or those taking other QT-prolonging medications. Consult your doctor before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy