Acetaminophen / Doxylamine
Acetaminophen/Doxylamine is a combination medication that pairs a pain reliever and fever reducer with a sedating antihistamine. This combination is typically used to provide nighttime relief from minor aches and pains while also helping individuals fall asleep. It is commonly found in over-the-counter products marketed for occasional nighttime pain or sleeplessness associated with discomfort.
A combination of pain/fever reliever and sleep aid used for nighttime symptom relief.
Key facts at a glance
- RxNorm
- 814290
- Generic
- Acetaminophen / Doxylamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves minor aches and pains (headache, muscle aches, backache, minor arthritis pain, toothache) and reduces fever while promoting drowsiness to aid sleep. Often used when pain or discomfort interferes with normal sleep.
Acetaminophen works by blocking pain signals in the brain and reducing fever through effects on the body's temperature-regulating center. Doxylamine is a first-generation antihistamine that crosses the blood-brain barrier and causes sedation by blocking histamine H1 receptors.
May cause drowsiness; avoid alcohol and activities requiring alertness. Do not exceed recommended dose as acetaminophen can cause serious liver damage. Should not be combined with other acetaminophen or antihistamine products. Consult a healthcare provider before use if pregnant, nursing, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy