Acetaminophen / Doxylamine / Phenylephrine
This combination medication provides multi-symptom relief for cold and flu by combining a pain reliever/fever reducer, an antihistamine, and a decongestant. It is commonly used to temporarily relieve symptoms such as headache, fever, body aches, sneezing, runny nose, and nasal congestion associated with the common cold or allergies.
A combination cold and flu medication that relieves pain, fever, allergies, and nasal congestion.
Key facts at a glance
- RxNorm
- 1006887
- Generic
- Acetaminophen / Doxylamine / Phenylephrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms of the common cold, flu, or allergies including headache, fever, body aches, sneezing, runny nose, itchy/watery eyes, and nasal congestion.
Acetaminophen reduces fever and pain; doxylamine blocks histamine to relieve allergy symptoms and may cause drowsiness; phenylephrine constricts blood vessels in the nasal passages to reduce congestion.
Do not exceed recommended dose; avoid alcohol; may cause drowsiness; consult a doctor if you have high blood pressure, heart disease, diabetes, thyroid problems, or are pregnant/nursing. Contains acetaminophen; do not use with other acetaminophen products.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy